Posterior Capsule Opacification: A Review of Experimental Studies

Posterior capsule opacification (PCO) is the most common complication of cataract surgery. It causes a gradual deterioration visual acuity, which would otherwise improve after successful procedure. Despite recent advances in ophthalmology, this has not been eradicated, and incidence PCO can be as high 10%. This article reviews literature concerning pathomechanism examines biochemical pathways involved its formation methods to prevent complication. We also review reported tests performed cell cultures under laboratory conditions experimental animal models ex vivo human lens capsules. Finally, we describe research involving eyes clinical setting pharmacological that may reduce frequency PCO. Due multifactorial etiology PCO, vitro studies make it possible assess factors contributing complications search for new therapeutic targets. Not all proliferation, migration, contraction are reproducible conditions; moreover, humans animals additionally stimulated by various degrees postoperative reactions depending on course Therefore, further necessary.